Methods library · Proteins and molecules
Analog-sensitive kinases (chemical genetics)
Also called bump-hole, Shokat method
Finding the direct substrates of one kinase by enlarging its ATP pocket so it alone uses a bulky labelled ATP analog.
Watch Give One Kinase an ATP of Its Own · 1:28
A schematic drawn in code, narrated by an AI narrator voice (Gemini, Charon) reading narration written from the lesson's text. First made for the lesson How We Know: Detecting a Signal.
Where it is taught
3 lessons use this method.